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CR1
CR1 (Complement C3b/C4b Receptor 1 (Knops Blood Group)) is a Protein Coding gene. Diseases associated with CR1 include Malaria and Plasmodium Falciparum Malaria. Among its related pathways are Creation of C4 and C2 activators and Primary Focal Segmental Glomerulosclerosis FSGS. Gene Ontology (GO) annotations related to this gene include complement component C3b binding and complement component C4b receptor activity. An important paralog of this gene is CSMD1.
Protein class
Blood group antigen proteins, CD markers, Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Kupffer cells, B-cells, Macrophages, Erythroid cells, monocytes)
Immune cell specificity
Group enriched (basophil, eosinophil, neutrophil)
Cell line specificity
Group enriched (HL-60, HMC-1, NB-4)
Interaction
Interacts (via Sushi 1 and Sushi 2 domains) with complement factor C4b (PubMed:2972794, 8175757). Interacts (via Sushi 8 and Sushi 9 domains) with complement factor C3b (PubMed:2972794, 8175757). Interacts (via Sushi 24 and Sushi 25 domains) with MBL2 (PubMed:23460739, 29563915). Interacts with FCN2 (PubMed:2972794). Interacts (via Sushi 24 and Sushi 25 domains) with C1QA (PubMed:9324355, 29563915). (Microbial infection) Interacts with Epstein-Barr virus gp350.
Molecular function
Blood group antigen, Host cell receptor for virus entry, Receptor
More Types Infomation
- Recombinant Human Anti-human CR1 Antibody Fab Fragment (MHH-240-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, Nert, FuncS
- Mouse Anti-CR1 Recombinant Antibody (clone HB8592); Fab Fragment (FAMAB-0310-CN-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-CR1 Recombinant Antibody (clone 8C12) (FAMAB-1102CQ)
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- Species Reactivity: Mouse
- Type: Mouse IgG1
- Application: FC
- Mouse Anti-CR1 Recombinant Antibody (clone HB8592) (FAMAB-0310-CN)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, IP, FuncS
- Mouse Anti-CR1 Recombinant Antibody (clone HB8592); scFv Fragment (FAMAB-0310-CN-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Recombinant Human Anti-human CR1 Antibody scFv Fragment (MHH-240-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: Neut, WB, FuncS
- Recombinant Anti-human CR1 Antibody scFv Fragment (MOB-240-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, FC, FuncS
- Recombinant Anti-human CR1 Antibody Fab Fragment (MOB-240-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, FACS, FuncS
- Mouse Anti-CR1 Antibody (clone HB8592), mRNA (FAMAB-0310-CN-mRNA)
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- Species Reactivity: Human
- Human Anti-CR1 Recombinant Antibody (clone E11) (FAMAB-1103CQ)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: IF, IP
- Human Anti-CR1 Antibody (clone E11), mRNA (FAMAB-1103CQ-mRNA)
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- Species Reactivity: Human
- Recombinant Anti-human CR1 Antibody (MOB-240)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, IF, FuncS
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
- Mouse Anti-CR1 Recombinant Antibody (clone J3D3) (NEUT-496CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: Block, ELISA, FC, IHC-Fr, IHC-P
- Mouse Anti-CR1 Recombinant Antibody (clone EDI19E9); scFv Fragment (HPAB-0423-CN-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Mouse Anti-CR1 Recombinant Antibody (clone EDIVH1/VL1); scFv Fragment (HPAB-0422-CN-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Mouse Anti-CR1 Recombinant Antibody (clone E11); scFv Fragment (HPAB-0421-CN-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Human Anti-CR1 Recombinant Antibody (clone EDI3G4); Fab Fragment (HPAB-0424-CN-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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