Cancer-related genes, Disease related genes, Human disease related genes
Intracellular
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Early spermatids, Astrocytes, Inhibitory neurons)
Low immune cell specificity
Low cell line specificity
Forms a complex named the PIDDosome with PIDD1 and CASP2 (PubMed:9044836, PubMed:8985253, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572). Interacts (via Death domain) with RIPK1 (via Death domain); the interaction is direct (PubMed:9044836). Interacts with TRADD (PubMed:8985253). Interacts with TNFRSF1A (PubMed:8985253).
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For Research Use Only. Not For Clinical Use.