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CREB5

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Protein class

Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Basal prostatic cells, Adipocytes, monocytes)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Cell line enhanced (HL-60, Karpas-707, U-2 OS, U-2197)

Interaction

Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.

Molecular function

Activator, DNA-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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