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CREG1
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Kupffer cells, Hofbauer cells, monocytes)
Immune cell specificity
Group enriched (classical monocyte, myeloid DC, intermediate monocyte, eosinophil, non-classical monocyte, basophil, neutrophil)
Cell line specificity
Cell line enhanced (RPMI-8226)
Interaction
Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation.
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP
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- Species Reactivity: Human
- Application: ELISA, IHC-P, WB
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For Research Use Only. Not For Clinical Use.