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CRTC1
CRTC1 (CREB Regulated Transcription Coactivator 1) is a Protein Coding gene. Diseases associated with CRTC1 include Mucoepidermoid Carcinoma and Clear Cell Hidradenoma. Among its related pathways are Mesodermal Commitment Pathway and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC2.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Horizontal cells, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 (PubMed:14536081). 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (PubMed:14536081). Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1 (PubMed:14536081). Interacts with 14-3-3 proteins, including YWHAE/14-3-3 epsilon (PubMed:30611118). Interacts with calmodulin-dependent catalytic subunit PPP3CA/calcineurin A (PubMed:30611118). (Microbial infection) Interacts with HTLV1 Tax.
Molecular function
Activator
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P, WB
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- Species Reactivity: Human
- Application: ELISA, FC, ICC/IF, WB
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- Derivation: Mouse
- Species Reactivity: Human, Pig, Mouse, Rat
- Type: Mouse IgG2b
- Application: ELISA, WB, ICC, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Monkey, Rat
- Type: Mouse IgM
- Application: WB, ICC
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For Research Use Only. Not For Clinical Use.