CRY1

Disease related genes, Human disease related genes

Intracellular

Cell type enhanced (Spermatocytes)

Low immune cell specificity

Low cell line specificity

Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins (By similarity). Interacts directly with TIMELESS (By similarity). Interacts directly with PER1 and PER3 (By similarity). Interacts directly with PER2; interaction with PER2 inhibits its ubiquitination and vice versa (PubMed:21613214). Interacts with FBXL21 (By similarity). Interacts with FBXL3 (PubMed:17463251). Interacts with PPP5C (via TPR repeats) (PubMed:16790549). Interacts with CLOCK-ARNTL/BMAL1 independently of PER2 and DNA (PubMed:28388406). Interacts with HDAC1, HDAC2 and SIN3B. Interacts with nuclear receptors AR, NR1D1, NR3C1/GR, RORA and RORC; the interaction with at least NR3C1/GR is ligand dependent (PubMed:22170608). Interacts with PRKDC (By similarity). Interacts with the G protein subunit alpha GNAS; the interaction may block GPCR-mediated regulation of cAMP concentrations (PubMed:20852621). Interacts with PRMT5 (PubMed:23133559). Interacts with EZH2 (By similarity). Interacts with MYBBP1A, DOCK7, HNRNPU, RPL7A, RPL8 and RPS3 (By similarity). Interacts with MAP1LC3B (By similarity). Interacts with CLOCK (By similarity). Interacts with ARNTL/BMAL1 (By similarity). Interacts weakly with HDAC3; this interaction is enhanced in the presence of FBXL3 (By similarity). Interacts with TRIM28, KCTD5 and DDB1 (By similarity). Interacts with FOXO1 (By similarity). Interacts with DTL and DDB1-CUL4A complex (PubMed:26431207). Interacts with HNF4A (PubMed:30530698). Interacts with PSMD2 in a KDM8-dependent manner (By similarity). Interacts with KDM8 in a FBXL3-dependent manner (By similarity). Interacts with PPARG in a ligand-dependent manner (By similarity). Interacts with PPARD (via domain NR LBD) and NR1I2 (via domain NR LBD) in a ligand-dependent manner (By similarity). Interacts with PPARA, NR1I3 and VDR (By similarity).

Photoreceptor protein, Receptor, Repressor