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CRYAB
CRYAB (Crystallin Alpha B) is a Protein Coding gene. Diseases associated with CRYAB include Myopathy, Myofibrillar, 2 and Cataract 16, Multiple Types. Among its related pathways are Protein processing in endoplasmic reticulum and Longevity regulating pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and microtubule binding. An important paralog of this gene is CRYAA.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Proximal tubular cells, Cardiomyocytes, Basal prostatic cells, Muller glia cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (ASC diff, fHDF/TERT166)
Interaction
Heteromer composed of three CRYAA and one CRYAB subunits (PubMed:20836128). Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes (PubMed:10751411). Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens (PubMed:22890888). Interacts with HSPBAP1 and TTN/titin (PubMed:14676215). Interacts with TMEM109 (PubMed:23542032). Interacts with DES; binds rapidly during early stages of DES filament assembly and a reduced binding seen in the later stages (PubMed:28470624). Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion (PubMed:32272059). Interacts with ATP6V1A and with MTOR, forming a ternary complex (PubMed:31786107).
Molecular function
Chaperone, Eye lens protein
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IHC-P, WB
- Rabbit Anti-CRYAB Recombinant Antibody (clone JA50-32) (MRO-0065-CN)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IF, IP
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC, ICC, IF, IHC, IP
- Recombinant Human Anti-CRYAB Soluble TCR (Ob.1A12) (KIH) (VS-0622-YF7024)
-
- Species Reactivity: Human
- Epitope: ITREEKPAVTAAPKK
- MHC: HLA-DRB1*15:01
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1, κ
- Application: WB
- Recombinant Human Anti-CRYAB Soluble TCR (Ob.1A12) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1608)
-
- Species Reactivity: Human
- Epitope: ITREEKPAVTAAPKK
- MHC: HLA-DRB1*15:01
- Human Anti-CRYAB Recombinant Soluble TCR (clone Ob.1A12) (scTCR-0307YC-S(P))
-
- Species Reactivity: Human
- Epitope: ITREEKPAVTAAPKK
- MHC: HLA-DRB1*15:01
-
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB, IHC
- Recombinant Human Anti-CRYAB Soluble TCR (Ob.1A12) (C-Cys) (VS-0622-YF4316)
-
- Species Reactivity: Human
- Epitope: ITREEKPAVTAAPKK
- MHC: HLA-DRB1*15:01
-
- Species Reactivity: E. coli, Human
- Type: Mouse IgG
- Application: WB, IHC, ELISA
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For Research Use Only. Not For Clinical Use.