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CST5

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity.
Protein class

Plasma proteins

Predicted location

Secreted

Single cell type specificity

Group enriched (Alveolar cells type 1, Langerhans cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Not detected

Interaction

Monomer.

Molecular function

Protease inhibitor, Thiol protease inhibitor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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