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CTSK
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Fibroblasts, Peritubular cells, Langerhans cells, Leydig cells, Melanocytes, Theca cells)
Immune cell specificity
Immune cell enhanced (classical monocyte)
Cell line specificity
Group enriched (ASC diff, ASC TERT1, BJ hTERT+)
Molecular function
Hydrolase, Protease, Thiol protease
More Types Infomation
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- Species Reactivity: Human
- Application: ELISA, IHC-P, WB
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For Research Use Only. Not For Clinical Use.