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CUBN
Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.
Protein class
Disease related genes, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Proximal tubular cells, Proximal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AN3-CA, ASC TERT1, SK-MEL-30, WM-115)
Interaction
Interacts with AMN (PubMed:14576052, PubMed:29402915, PubMed:20237569, PubMed:30523278). Component of the cubam complex composed of one CUBN trimer and one AMN chain (PubMed:30523278). The cubam complex can dimerize (By similarity). Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner. Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and PID1/PCLI1.
Molecular function
Receptor
More Types Infomation
- Rabbit Anti-CUBN Recombinant Antibody (clone JB42-13) (MRO-0401-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
- Recombinant Anti-Human CUBN Antibody scFv Fragment (MOB-1811z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, Neut, Biosensors, FuncS
- Recombinant Anti-Human CUBN Antibody Fab Fragment (MOB-1811z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, FuncS
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For Research Use Only. Not For Clinical Use.