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CX3CL1

Fractalkine is a unique Th1 CX3C chemokine known to induce adhesion and migration of leukocytes mediated by both, a membrane-bound and soluble form, respectively.
Protein class

Plasma proteins

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Adipocytes, Breast glandular cells, Club cells, Basal respiratory cells, Breast myoepithelial cells, Basal prostatic cells, Endothelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (EFO-21, HDLM-2, Hep G2, RPTEC TERT1, SK-BR-3)

Interaction

Monomer (PubMed:9931005). Forms a ternary complex with CX3CR1 and ITGAV:ITGB3 or ITGA4:ITGB1 (PubMed:23125415). (Microbial infection) Interacts with pox virus crmD; this inhibits cell migration mediated by CX3CL1. (Microbial infection) Interacts (via N-terminus) with human cytomegalovirus (HHV-5) US28.

Molecular function

Cytokine

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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