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CXCL14

This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation.
Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Proximal tubular cells, Basal keratinocytes, Basal squamous epithelial cells, Fibroblasts, Suprabasal keratinocytes, Breast myoepithelial cells, Glandular and luminal cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (HAP1, hTCEpi, RPTEC TERT1, SuSa, U-2 OS)

Molecular function

Cytokine

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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