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CXCR3

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
Protein class

CD markers, G-protein coupled receptors

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (dendritic cells, T-cells, Plasma cells, Proximal enterocytes, NK-cells)

Immune cell specificity

Immune cell enhanced (plasmacytoid DC)

Cell line specificity

Cell line enriched (RPMI-8226)

Interaction

Homomer. Forms heteromers with ACKR4.

Molecular function

G-protein coupled receptor, Receptor, Transducer

More Types Infomation
  • IP10-DT immunotoxin (AGTO-L073D)
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Functional assay

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