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CYBA
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Hofbauer cells, Plasma cells, NK-cells, Kupffer cells, monocytes, Macrophages, dendritic cells)
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Cell line enhanced (MCF7, RPMI-8226, THP-1)
Interaction
Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain). Interacts with SH3PXD2A (By similarity). Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX3 and NOX4. Interacts with calprotectin (S100A8/9) (PubMed:22808130). Interacts with GBP7 (By similarity).
Molecular function
Oxidoreductase
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, IHC, IP
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.