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CYBB
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Macrophages, Kupffer cells, monocytes, Hofbauer cells)
Immune cell specificity
Immune cell enhanced (classical monocyte, intermediate monocyte)
Cell line specificity
Group enriched (Daudi, NB-4, REH, RPMI-8226)
Interaction
Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1. Interacts with calprotectin (S100A8/9). Interacts with NRROS; the interaction is direct and impairs formation of a stable NADPH oxidase complex (PubMed:19028840, PubMed:3600769, PubMed:9224653). Interacts with CYBC1; CYBC1 may act as a chaperone stabilizing Cytochrome b-245 heterodimer (PubMed:28351984). Interacts with NCF2; the interaction is enhanced in the presence of GBP7 (By similarity). The CYBA-CYBB complex interacts with GBP7 (By similarity).
Molecular function
Ion channel, Oxidoreductase, Voltage-gated channel
More Types Infomation
- Rabbit Anti-CYBB Recombinant Antibody (clone CBACN-406) (MRO-1104-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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- Species Reactivity: Human
- Application: ICC/IF, IHC-P, WB
- Rabbit Anti-CYBB Polyclonal Antibody (MRO-2082-CN) (MRO-2082-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
- Mouse Anti-CYBB Recombinant Antibody (clone NL7) (VS1-YJ152)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
- Mouse Anti-CYBB Recombinant Antibody (clone CL5) (VS1-YJ151)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IF, IHC-P
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.