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DAPK2
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Late spermatids, Oligodendrocytes, Alveolar cells type 1, Proximal enterocytes)
Immune cell specificity
Group enriched (eosinophil, basophil, neutrophil)
Cell line specificity
Cell line enhanced (ASC diff, HaCaT, HMC-1, MCF7)
Interaction
Homodimer in its autoinhibited state. Active as monomer (By similarity). Isoform 2 but not isoform 1 can interact with ATF4. Interacts with 14-3-3 proteins YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN; the interaction requires DAPK2 phosphorylation at Thr-369 and suppresses DAPK2 kinase activity and DAPK2-induced apoptosis (PubMed:26047703).
Molecular function
Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
Related Diseases
Bladder Cancer
- Recombinant Mouse Anti-Human DAPK2 Antibody (MOB-1514MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
-
- Species Reactivity: Rat
- Type: Rabbit IgG
- Application: WB, IHC-P
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: IHC, ELISA
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For Research Use Only. Not For Clinical Use.