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DCC
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons, Early spermatids, Late spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (AF22, U-266/70, U-266/84)
Interaction
Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D (By similarity). Interacts with DSCAM (By similarity). Interacts with PTK2/FAK1 and MAPK1 (By similarity). Interacts with NTN1 (By similarity). Interacts with MYO10 (PubMed:21642953). Interacts with CBLN4; this interaction can be competed by NTN1 (By similarity). Interacts with SIAH1 and SIAH2 (PubMed:9334332).
Molecular function
Developmental protein, Receptor
More Types Infomation
- Rabbit Anti-DCC Polyclonal Antibody (MRO-2066-CN) (MRO-2066-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P
- Mouse Anti-DCC Recombinant Antibody (clone Axel-1) (NEUT-700CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2a, λ
- Application: Neut, FC
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For Research Use Only. Not For Clinical Use.