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DCP1A
Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants.
Protein class
Plasma proteins, Transporters
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3 (PubMed:16364915). Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1 (PubMed:12515382). Interacts with DCP1B (PubMed:12417715). Interacts with DCP2 (PubMed:12417715). Interacts with DDX17 in an RNA-independent manner (PubMed:21876179). Interacts with PNRC2 (PubMed:19150429). Interacts with SMAD4 (PubMed:11836524). Interacts with UPF1 (PubMed:12417715). Interacts with ZC3HAV1 (PubMed:21876179). Interacts with ZFP36L1 (PubMed:15687258). Interacts with NBDY (PubMed:27918561). Interacts with DHX34; the interaction is RNA-independent (PubMed:25220460).
Molecular function
Hydrolase
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: FC, IHC-P, WB, ICC, IF
- Recombinant Mouse Anti-Human DCP1A Antibody (MOB-1348MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC, WB
- Rabbit Anti-DCP1A Recombinant Antibody (clone JB51-34) (MRO-0461-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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For Research Use Only. Not For Clinical Use.