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DCTN4

DCTN4 (Dynactin Subunit 4) is a Protein Coding gene. Diseases associated with DCTN4 include Cystic Fibrosis. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding.
Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres (By similarity).

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For Research Use Only. Not For Clinical Use.

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