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DDR2
This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia.
Protein class
Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Fibroblasts, Skeletal myocytes, Endometrial stromal cells, Peritubular cells, Smooth muscle cells, Leydig cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, fHDF/TERT166, HSkMC)
Interaction
Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1.
Molecular function
Kinase, Receptor, Transferase, Tyrosine-protein kinase
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, ICC/IF, IHC-P, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
- Anti-Human DDR2 Recombinant Antibody (TAB-212CL)
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- Species Reactivity: Human
- Type: Antibody
- Mouse Anti-DDR2 Recombinant Antibody; Fab Fragment (TAB-186MZ-F(E)) (TAB-186MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-DDR2 Recombinant Antibody; Fab Fragment (TAB-185MZ-F(E)) (TAB-185MZ-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-DDR2 Recombinant Antibody; scFv Fragment (TAB-186MZ-S(P)) (TAB-186MZ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-DDR2 Recombinant Antibody; scFv Fragment (TAB-185MZ-S(P)) (TAB-185MZ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, IF, ELISA
- Human Anti-DDR2 Antibody, mRNA (TAB-212CL-mRNA)
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- Species Reactivity: Human
- Mouse Anti-DDR2 Recombinant Antibody (TAB-186MZ) (TAB-186MZ)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FuncS
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- Species Reactivity: Human
- Type: ADCC enhanced antibody
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB, IHC, ICC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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For Research Use Only. Not For Clinical Use.