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DDX20
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs.
Protein class
Enzymes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Early spermatids, Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP (PubMed:10601333, PubMed:17178713). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG (PubMed:18984161, PubMed:12095920). Interacts with SMN1; the interaction is direct (PubMed:17178713). Interacts with GEMIN4; the interaction is direct (PubMed:17178713). Interacts with GEMIN5 (PubMed:33963192). Interacts with SNUPN; the interaction is direct (PubMed:12095920). Interacts with PPP4R2 (PubMed:12668731). Interacts with FOXL2 (PubMed:16153597). Interacts with EBV EBNA2 and EBNA3C (PubMed:10383418). Interacts with NANOS1 and PUM2 (PubMed:21800163).
Molecular function
DNA-binding, Helicase, Hydrolase
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, ICC/IF, IP, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF, FC
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- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse IgG1
- Application: WB, ICC, FC
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- Species Reactivity: Human, Rat, Mouse, Hamster
- Type: Mouse IgG1
- Application: ELISA, IF, WB, IP
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For Research Use Only. Not For Clinical Use.