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DDX4

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Protein class

Enzymes

Predicted location

Intracellular

Single cell type specificity

Group enriched (Early spermatids, Spermatocytes, Late spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BEWO, PC-3)

Interaction

Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4 (By similarity). Interacts with RANBP9 (PubMed:27622290). Interacts with RANBP10. Interacts with PIWIL2 and MAEL. Interacts with ARNTL/BMAL1 and CLOCK. Interacts with Tex19.1 and, probably, Tex19.2 (By similarity).

Molecular function

Developmental protein, Helicase, Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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