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DEFB1

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]
Protein class

Transporters

Predicted location

Secreted

Single cell type specificity

Cell type enriched (Distal tubular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (SCLC-21H)

Interaction

Monomer (PubMed:23938203). Homodimer (PubMed:23938203).

Molecular function

Antibiotic, Antimicrobial, Defensin

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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