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DLX2
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Early spermatids, dendritic cells, Gastric mucus-secreting cells, Melanocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (AN3-CA, HEK93)
Interaction
Interacts (via homeobox DNA-binding domain) with POU4F2; this interaction enhances retinal ganglion cell (RGC) differentiation.
Molecular function
Activator, Developmental protein, DNA-binding
More Types Infomation
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- Species Reactivity: Human
- Application: IHC-P, WB
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For Research Use Only. Not For Clinical Use.