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DLX4

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.
Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Extravillous trophoblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BEWO, CACO-2, GAMG, HAP1, K-562)

Molecular function

Developmental protein, DNA-binding

More Types Infomation

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