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DMC1

This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants.
Predicted location

Intracellular

Single cell type specificity

Group enriched (Spermatocytes, Spermatogonia)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HDLM-2, hTEC/SVTERT24-B, U-266/84)

Interaction

Double stacked ring-shaped homooctamer (PubMed:15125839). Interacts with BRCA2 (PubMed:20729832). Interacts with the MND1-PSMC3IP heterodimer (By similarity). Interacts with RAD51AP1; the interaction is direct and stimulates DMC1-mediated homologous recombination (PubMed:21307306, PubMed:21903585).

Molecular function

DNA-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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