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DNAI2
The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Respiratory ciliated cells, Endometrial ciliated cells, Spermatocytes, Early spermatids, Late spermatids)
Immune cell specificity
Immune cell enriched (NK-cell)
Cell line specificity
Cell line enriched (HMC-1)
Interaction
Consists of at least two heavy chains and a number of intermediate and light chains (Probable). Interacts with DNAAF2 (By similarity). Interacts with DNAAF6/PIH1D3 (PubMed:28176794). Interacts with HEATR2; probably involved in outer arm dynein assembly (PubMed:25232951).
Molecular function
Motor protein
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
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For Research Use Only. Not For Clinical Use.