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DNM2
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Distal enterocytes, Paneth cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with MYOF (By similarity). Interacts with CTTN and ACTN1 (By similarity). Interacts with SHANK1, SHANK2, SH3BP4 and NOSTRIN. Interacts with SNX9 (PubMed:15703209). Interacts with SNX18 (PubMed:29437695). Interacts with SNX33 (via SH3 domain) (PubMed:18353773). Interacts with MYO1E (via SH3 domain) (PubMed:17257598). Interacts with PSTPIP1 (PubMed:18480402). Interacts with CTNND2 (PubMed:22022388). May interact with PIK3C3 (By similarity). May be a component of a complex composed of RAB5A (in GDP-bound form), DYN2 and PIK3C3 (By similarity). Interacts with BIN1 (PubMed:17676042).
Molecular function
Hydrolase, Motor protein
More Types Infomation
- Rabbit Anti-DNM2 Recombinant Antibody (clone JM61-38) (MRO-0501-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, IHC-Fr, IHC-P, WB
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- Derivation: Phage display library
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF, FC
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: ELISA, WB, IF, FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, ELISA
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For Research Use Only. Not For Clinical Use.