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DNMBP
DNMBP belongs to the DBL (MIM 311030) family of guanine nucleotide exchange factors and plays a role in the regulation of cell junctions.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (hTERT-RPE1)
Interaction
Binds DNM1 via its N-terminal SH3 domains. The C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 and actin-regulatory proteins, such as ENAH, EVL, WIRE, CR16, WAVE1 and NAP1L1 (By similarity). Interacts with FASLG (PubMed:19807924). Interacts (via SH3 domain 6) with WASL (PubMed:19767742, PubMed:24332715, PubMed:17015620). Interacts (via SH3 domain 6) interacts with ENAH (PubMed:24332715). Interacts (via C-terminal domain) with TJP1; required for the apical cell-cell junction localization of DNMBP (PubMed:17015620). (Microbial infection) Interacts (via SH3 domain 6) with L.monocytogenes InlC.
Molecular function
Guanine-nucleotide releasing factor
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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- Derivation: Phage display library
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.