Plasma proteins
Intracellular
Group enriched (Microglial cells, Oligodendrocytes, Astrocytes, Oligodendrocyte precursor cells, Excitatory neurons)
Immune cell enriched (neutrophil)
Cell line enhanced (hTEC/SVTERT24-B, HUVEC TERT2, TIME)
Interacts with nucleotide-free Rap1; functions as a guanine nucleotide exchange factor (GEF) for Rap1 (PubMed:12628187). Interacts (via DOCKER domain) with RAC1; functions as a guanine nucleotide exchange factor (GEF) for RAC1 (PubMed:16464467). Interacts with the SH3 domain of CRK (PubMed:12628187). Interacts with FASLG (PubMed:19807924). Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2 (PubMed:20679435). Interacts with USH1C (via PDZ 1 domain) (PubMed:16464467).
Guanine-nucleotide releasing factor
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For Research Use Only. Not For Clinical Use.