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DOK2

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (NK-cells, Langerhans cells, Macrophages, Kupffer cells, T-cells, Hofbauer cells, dendritic cells)

Immune cell specificity

Immune cell enhanced (eosinophil)

Cell line specificity

Cell line enhanced (HDLM-2, HEL, HMC-1, JURKAT, THP-1, U-937)

Interaction

Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK. Interacts (via PH domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). (Microbial infection) Interacts with Herpes simplex virus 1 (HHV-1) protein UL46; this interaction induces DOK2 phosphorylation and subsequent degradation.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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