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DPYD
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Oligodendrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer.
Molecular function
Oxidoreductase
More Types Infomation
- Recombinant Anti-human DPYD Antibody (MOB-289)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, IF, FuncS
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC, ICC/IF, IHC-P, WB
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, FuncS
- Recombinant Anti-human DPYD Antibody scFv Fragment (MOB-289-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IP, FuncS
- Recombinant Anti-human DPYD Antibody Fab Fragment (MOB-289-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IF, FC, FuncS
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC
- Recombinant Human Anti-human DPYD Antibody scFv Fragment (MHH-289-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: FC, RIA, Biosensors, FuncS
- Recombinant Human Anti-human DPYD Antibody Fab Fragment (MHH-289-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, FC, FuncS
-
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, IF
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For Research Use Only. Not For Clinical Use.