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DSP
Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Suprabasal keratinocytes, Squamous epithelial cells, Basal keratinocytes, Cardiomyocytes)
Immune cell specificity
Immune cell enriched (naive B-cell)
Cell line specificity
Cell line enhanced (BEWO, HaCaT, HBEC3-KT, hTCEpi, SuSa)
Interaction
Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with DSC2. Interacts with PKP2. Interacts weakly with TMEM65 (By similarity).
More Types Infomation
- Mouse Anti-DSP Recombinant Antibody (clone 41G1) (MOB-2025z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IF, IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IF, WB
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- Species Reactivity: Human
- Application: ICC, ICC/IF, WB, IHC-Fr
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For Research Use Only. Not For Clinical Use.