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DYRK1B
This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Group enriched (Late spermatids, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (SH-SY5Y)
Interaction
Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A (PubMed:11980910). Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5 (PubMed:14500717). Interacts with DCAF7 (PubMed:14593110). Interacts with RNF169 (PubMed:33469661).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC
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For Research Use Only. Not For Clinical Use.