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E2F5
Protein class
Cancer-related genes, Transcription factors
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Plasma cells, B-cells)
Immune cell specificity
Group enriched (memory B-cell, naive B-cell)
Cell line specificity
Cell line enhanced (AF22, Daudi, U-698)
Interaction
Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interaction with retinoblastoma protein RB1 or proteins RBL1 and RBL2 inhibits the E2F transactivation domain. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.
Molecular function
Activator, DNA-binding
More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.