Intracellular
Low cell type specificity
Low immune cell specificity
Low cell line specificity
Interacts with TP53, MDM2, TXNIP (PubMed:16849563, 23880345). Interacts (phosphorylated) with PIH1D1. Interacts with RUVBL1 mediating the PIH1D1-independent association with the R2TP complex (PubMed:24656813, 26711270). Interacts with RB1, RBL1 and RBL2; ECD competes with E2F1 for binding to hypophospshorylated RB1 (PubMed:19640839). Interacts with EP300 (PubMed:19919181).
Activator
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For Research Use Only. Not For Clinical Use.