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EFNA2

This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.
Protein class

Cancer-related genes, RAS pathway related proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Oligodendrocyte precursor cells, Cardiomyocytes, Paneth cells, Inhibitory neurons, Basal keratinocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AF22, CACO-2, Hep G2, NTERA-2, OE19, REH, SH-SY5Y)

Interaction

Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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