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EGLN2
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene.
Protein class
Enzymes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts (preferably isoform p40) with SIAH2; the interaction targets both SIAH2 isoforms for proteasomal degradation in vitro (PubMed:16509823). Interacts with LIMD1, WTIP and AJUBA (PubMed:22286099).
Molecular function
Dioxygenase, Oxidoreductase
More Types Infomation
- Rabbit Anti-EGLN2 Recombinant Antibody (clone CBACN-443) (MRO-1219-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA
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- Species Reactivity: Human
- Application: IHC-P, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IP
- Rabbit Anti-EGLN2 Recombinant Antibody (VS3-WK1106) (VS3-WK1106)
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, FC
-
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.