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EIF4EBP3

This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]
Protein class

Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Basal squamous epithelial cells, Proximal enterocytes, Squamous epithelial cells, Exocrine glandular cells, Gastric mucus-secreting cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HHSteC, JURKAT, Karpas-707)

Interaction

EIF4EBP3 interacts with EIF4E.

Molecular function

Protein synthesis inhibitor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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