Cancer-related genes, Transcription factors
Intracellular
Cell type enhanced (Urothelial cells, Distal enterocytes, Paneth cells, Proximal enterocytes, Gastric mucus-secreting cells)
Not detected in immune cells
Cell line enhanced (A549, CAPAN-2, OE19, RT4, SK-BR-3)
Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3.
Activator, Developmental protein, DNA-binding, Repressor
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For Research Use Only. Not For Clinical Use.