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ELF3

ELF3 (E74 Like ETS Transcription Factor 3) is a Protein Coding gene. Diseases associated with ELF3 include sarcoma, synovial and n syndrome. Among its related pathways are EGFR1 Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is ELF4.
Protein class

Cancer-related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Urothelial cells, Distal enterocytes, Paneth cells, Proximal enterocytes, Gastric mucus-secreting cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (A549, CAPAN-2, OE19, RT4, SK-BR-3)

Interaction

Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3.

Molecular function

Activator, Developmental protein, DNA-binding, Repressor

More Types Infomation

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