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EME1

This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability.
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Spermatocytes, Spermatogonia, Extravillous trophoblasts, Cytotrophoblasts, Granulosa cells)

Immune cell specificity

Immune cell enriched (basophil)

Cell line specificity

Low cell line specificity

Interaction

May self-associate. Interacts with MUS81.

Molecular function

Endonuclease, Hydrolase, Nuclease

More Types Infomation

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