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ENC1
This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein class
Cancer-related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Theca cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Binds to RB1. Hypophosphorylated RB1 associates with ENC1 during neuronal differentiation, while hyperphosphorylated RB1 associates with ENC1 in undifferentiating cells. Part of a complex that contains CUL3, RBX1 and ENC1. Interacts indirectly with KEAP1.
Molecular function
Actin-binding, Developmental protein
More Types Infomation
- Recombinant Mouse Anti-Human ENC1 Antibody (MOB-0746MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC
- Chicken Anti-ENC1 Polyclonal IgY (BRD-0785MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: ICC, IF, IHC, WB
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For Research Use Only. Not For Clinical Use.