Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
Loading...
Custom Services order now ship next day

EPHA1

Engineered Antibody
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.
Protein class

Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Squamous epithelial cells, Early spermatids, Gastric mucus-secreting cells, Proximal enterocytes)

Immune cell specificity

Group enriched (naive CD4 T-cell, naive CD8 T-cell, memory CD4 T-cell)

Cell line specificity

Cell line enhanced (CACO-2, HaCaT, HBEC3-KT, MCF7, NTERA-2)

Interaction

Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2/FAK1.

Molecular function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

More Types Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

For Research Use Only. Not For Clinical Use.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart
    Inquiry

    Go to compare