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EPHB1
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Astrocytes, Oligodendrocyte precursor cells, dendritic cells, Excitatory neurons, Inhibitory neurons, Early spermatids, Late spermatids)
Immune cell specificity
Group enriched (neutrophil, plasmacytoid DC)
Cell line specificity
Group enriched (HDLM-2, HMC-1, RPTEC TERT1)
Interaction
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts with EPHB6; transphosphorylates EPHB6 to form an active signaling complex. Interacts with PICK1 (By similarity). Interacts (through Tyr-594) with NCK1 (via SH2 domain); activates the JUN cascade to regulate cell adhesion (By similarity). The ligand-activated form interacts (through Tyr-928) with GRB7 and GRB10 (via SH2 domains). The ligand-activated form interacts (residues within the catalytic domain) with GRB2 (via SH2 domain). Interacts with GRB2, SHC1 and SRC; activates the MAPK/ERK cascade to regulate cell migration. Interacts with CBL; regulates receptor degradation through ubiquitination. Interacts with ACP1.
Molecular function
Kinase, Receptor, Transferase, Tyrosine-protein kinase
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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- Species Reactivity: Human
- Application: ELISA, IHC-P, WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, ELISA
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For Research Use Only. Not For Clinical Use.