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EPPIN
This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene.
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Group enriched (Respiratory ciliated cells, Endometrial ciliated cells, Late spermatids, Granulosa cells, Sertoli cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (Karpas-707, U-87 MG)
Interaction
Monomer. Homodimer. Homomultimers. Interacts with SEMG1 (via 164-283 AA). Interacts with LTF. Found in a complex with LTF, CLU, EPPIN and SEMG1.
Molecular function
Antimicrobial, Protease inhibitor, Serine protease inhibitor
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgM
- Application: WB, ELISA, IP
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For Research Use Only. Not For Clinical Use.