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EREG

This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues.
Protein class

Human disease related genes

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Macrophages, Basal respiratory cells, Langerhans cells, Kupffer cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BJ hTERT+, CAPAN-2, hTEC/SVTERT24-B, U-2197, U-87 MG)

Interaction

Interacts with EGFR and ERBB4.

Molecular function

Developmental protein, Growth factor, Mitogen

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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