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ETS1

This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Protein class

Plasma proteins, RAS pathway related proteins, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (NK-cells, dendritic cells, T-cells, Adipocytes, Hepatic stellate cells, Endothelial cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HEL, JURKAT, U-698)

Interaction

Binds DNA as a homodimer; homodimerization is required for transcription activation. Interacts with MAF and MAFB. Interacts with PAX5; the interaction alters DNA-binding properties (By similarity). Interacts with DAXX. Interacts with UBE2I. Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional activity.

Molecular function

DNA-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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