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EYA2

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined.
Protein class

Enzymes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Astrocytes, Glandular and luminal cells, Basal respiratory cells, Oligodendrocyte precursor cells, Basal prostatic cells, Endometrial ciliated cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HBEC3-KT, SCLC-21H, U-266/70, U-266/84)

Interaction

Interacts with DACH2 and SIX1, and probably with SIX2, SIX4 and SIX5. Interacts with CAPN8 (By similarity). Interacts with GNAZ and GNAI2; this precludes interaction with SIX1.

Molecular function

Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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