Intracellular
Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Hofbauer cells, Extravillous trophoblasts, Cardiomyocytes)
Low immune cell specificity
Low cell line specificity
Component of the CIA complex (PubMed:22678361, PubMed:22678362, PubMed:23585563). Component of the MMXD complex, which includes CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5 (PubMed:20797633). Interacts with CIAO1, ERCC2 and MMS19; the interactions are direct (PubMed:22678362, PubMed:23585563). Interacts with KIF4A; the interaction facilitates the transfer of Fe-S clusters to KIF4A to ensure proper localization of KIF4A to the mitotic machinery (PubMed:29848660). Interacts with CCDC117; the interaction is direct (PubMed:30742009).
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For Research Use Only. Not For Clinical Use.