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FBXL13
Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids, Oligodendrocyte precursor cells, Oligodendrocytes)
Immune cell specificity
Group enriched (neutrophil, eosinophil)
Cell line specificity
Cell line enhanced (HEL, HUVEC TERT2, U-266/84, U-87 MG, U-937)
Interaction
Component of the nexin-dynein regulatory complex (N-DRC). Directly interacts with SKP1 and CUL1. Interacts with TCTE1/DRC5.
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.